CBN vs CBD: Key Differences and Benefits

CBN vs CBD: Key Differences and Benefits

Table of Contents

Cannabidiol, or CBD, became something of a household name following the 2018 Farm Bill, which made hemp-derived CBD products with less than 0.3% THC federally legal. It led to a veritable CBD boom as people began incorporating these products into their daily wellness practices.

As familiarity with this cannabinoid increased, so did a growing interest in minor cannabinoids. CBN, or cannabinol, is one of them. It’s not as readily available as CBD, and there’s far less research on its benefits. Still, CBN is nevertheless slowly growing in popularity for its role in promoting sleep and pain management. Here’s what to understand about the differences between CBN and CBD, and which cannabinoid is best for you.

What is CBD?

CBD is one of some 100 identified cannabinoids, or compounds, in the cannabis plant. It’s often the second most abundant cannabinoid in these plants after THC (tetrahydrocannabinol), and one of its central claims to fame is that it doesn’t have a psychoactive effect, which means it doesn’t produce the “high” associated with cannabis as a whole (THC gets the credit for that). Instead, CBD has a therapeutic role, with many people using it for stress management, to improve sleep, or to manage chronic pain and inflammation.

CBD is extracted from hemp plants in several ways, and the resulting oil can be blended into a range of products. Here at Cornbread Hemp, we utilize organic sugarcane ethanol to extract our Flower Only Hemp CBD extract, which is made without leaves or stems, resulting in a higher-quality, better-tasting finished oil. We’re proud to use USDA-certified organic Kentucky hemp in most of our CBD products, including gummies, tinctures, and topicals.

What is CBN?

CBN is considered one of the minor cannabinoids in the cannabis plant because it’s only found in trace amounts. A little science lesson: CBN comes from the degradation of THCa, or tetrahydrocannabinol acid, which happens when cannabis is exposed to air or UV light for prolonged periods. THCa degrades into cannabinol acid, or CBNa, which becomes CBN during the chemical reaction known as decarboxylation. That’s actually why it’s typically found in greater quantities in older cannabis plants.

While CBN is technically psychoactive, it’s subtle enough that it doesn’t have an intoxicating effect (and it’s nothing at all like the euphoria or altered perception typical of THC). Still, in large quantities, CBN can produce mild psychoactive reactions. Usually, though, this cannabinoid creates a sedated effect or a feeling of relaxation.

It hasn’t been studied as much as CBD or THC, so information at this point is largely speculative. However, it may offer calming, sleep-supporting benefits, making it an appealing alternative to other sleep aids. It's often described as "the sleepy cannabinoid." There’s also some suggestion that CBN might have anti-inflammatory benefits, which we’ll cover below.

CBD and CBN, health benefits, other cannabinoids, mild psychoactive reactions, minor cannabinoid

Key differences between CBD and CBN

While their names are similar, CBN and CBD are separate molecules and differ in structure, origin, and potential effects on the body. Let’s break it down.

Structural differences

As different compounds, CBN and CBD have distinct molecular structures (although the differences are slight). Still, it’s enough to influence how these cannabinoids interact with the receptors in the endocannabinoid system.

We’ve already mentioned that CBD is a primary cannabinoid found in abundance in hemp plants in particular. That means it’s relatively easy to extract in large quantities for CBD products. Plus, it’s possible to breed cannabis plants with higher levels of CBD.

CBN is different. Because it’s created from the breakdown of THC that’s been exposed to heat, light, and oxygen, it’s only found in trace amounts in older cannabis plants. The amounts are so small that CBN must be carefully extracted and concentrated for use in products like tinctures or sleep gummies. That’s why it’s primarily found in specialty sleep products.

Full-spectrum CBD products, like those here at Cornbread Hemp, include the full range of cannabinoids naturally found in the hemp plant, like CBD, up to 0.3% THC, and yep, trace amounts of CBN.

Interaction with the endocannabinoid system

Both CBD and CBN interact with the body’s endocannabinoid system, a complex and extensive network that regulates balance, or homeostasis. Things like appetite, digestion, immune function, stress and pain responses, mood, and memory are all managed by the ECS, which has three parts:

  • Endocannabinoids, which are naturally produced on demand
  • Cannabinoid receptors (CB1 and CB2), which are located throughout the body
  • Enzymes, which limit the production of endocannabinoids and help break them down after they’ve interacted with receptors

The interesting thing is that cannabinoids from the cannabis plant mimic the endocannabinoids produced in the body, which is why they’re capable of interacting with the ECS. Researchers are still puzzling out exactly how this happens. Still, they believe that CBD influences CB1 and CB2 receptors indirectly rather than binding directly to them (CB1 receptors are mostly found in the brain and nervous system, while CB2 receptors are primarily clustered in the immune system and peripheral tissues). That’s why it has therapeutic effects.

CBN, on the other hand, appears to interact lightly with CB1 receptors. The same is true of THC, though its interaction is much stronger, creating a strong psychoactive effect. The effect of CBN is much more subtle. This cannabinoid may also interact with CB2 receptors, which are associated with inflammation and immune function.

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Effects

Because CBD and CBN interact differently with the ECS, their effects are likewise different. People use CBD for multiple reasons, including stress management, reducing inflammation, and promoting general relaxation. Some people use it as part of their daily wellness routine to encourage a sense of calm. Others use it to target anxiety, insomnia, and chronic conditions.

Remember, CBD isn’t psychoactive, and it’s widely available thanks to the 2018 Farm Bill, so it’s appealing to people who want to benefit from the effects of the cannabis plant but avoid any intoxicating effects.

CBN isn’t as well studied, so there is limited scientific evidence; however, anecdotal evidence suggests it can be used as a sleep aid and to help manage pain. That’s thanks to CBN's sedative properties, which are stronger compared to CBD and make it easier to stay asleep. Research is still limited, but a 2024 double-blind, placebo-controlled, randomized study found that 20mg of CBN reduced nighttime awakenings and overall sleep disturbances compared to the placebo.

Regarding pain relief, a 2019 rodent study found that both CBD and CBN reduced myofascial pain in rats. While human clinical trials are warranted, researchers concluded that these cannabinoids could be effective at relieving pain from fibromyalgia and certain disorders.

Legality of CBD and CBN

CBD and CBN are both legal on a federal level and in most states because of the 2018 Farm Bill, which legalized hemp-derived products that contain less than 0.3% THC. Still, state laws can and do vary. Some have restrictions on hemp-derived cannabinoids or specific testing requirements. That's not a bad thing since quality control for CBD and CBN products can vary pretty significantly.

Remember to check your state's laws before purchasing or using CBD and CBN products, and always look for brands that provide certificates of analysis from third-party labs. That's the only way to ensure that the products are safe to use and legally compliant.

How to choose between CBD and CBN

At this point, you might be wondering whether CBD or CBN is better for you. Like all things cannabis, it really comes down to individual needs and preferences. There's no question that CBD products are more popular and certainly more widely available than CBN products. For those who are interested in a non-psychoactive compound, they're clearly the better choice. But if you're having trouble sleeping, a CBN product may be a better option.

Keep in mind that full-spectrum CBD products, like those here at Cornbread Hemp, have, well, the full spectrum of cannabinoids in the hemp plant, including up to 0.3% THC and all of the minor cannabinoids. If you're investigating CBN for its sleep benefits, our CBD Sleep Gummies might be worth a look. Still, we recommend consulting your healthcare professional if you need help figuring out the best course of action.

The Bottom Line

In the CBN vs CBD debate, there's really no clear winner. Choosing between these cannabinoids ultimately comes down to what you hope to accomplish. CBD and CBN both offer potential benefits, so consider what matters most to you. Traditionally, CBD is used for everyday support, especially for stress relief and relaxation. CBN, on the other hand, is known for its calming and sleep-supportive qualities, making it a natural sleep aid.

The best of both worlds may be a full-spectrum CBD product that gives you the benefit of the entourage effect, which is what you'll find right here at Cornbread Hemp.

About the Author
Jessica Timmons

Jessica Timmons brings close to two decades of writing and editing experience to Cornbread Hemp. Her work has appeared on Healthline, Forbes Vetted, Fortune Recommends, mindbodygreen, Everyday Health and other prominent outlets. When she's not working, she loves traveling the world with her husband and four kids, practicing yoga, lifting weights and enjoying her drink du jour: a London Fog with oat milk. See what she's up to these days on her website. Full author bio here.

Frequently Asked Questions

It depends on your goal, though there is more clinical research into CBD than CBN. CBD is also more versatile, as it can be used for daily wellness, stress relief, and alleviating mild discomfort. CBN is typically used specifically for sleep support. The better choice ultimately depends on what you’re looking for—for overall balance, CBD is probably the better option, but for improved sleep, CBN may be a more targeted choice.

CBN has sedative properties, so it can make people feel really calm and relaxed. In high doses, it can have a very mild psychoactive effect, but it’s not comparable to the “high” of THC. 

Some clinical research suggests it may improve sleep by reducing nighttime awakenings and overall sleep disturbances; however, there is no evidence that it accelerates the time to fall asleep. Still, it appeals to people seeking a natural sleep aid, as it may improve overall sleep quality.

References

  1. Cannabis (Marijuana) and Cannabinoids: What You Need To Know. https://www.nccih.nih.gov Accessed December 2, 2025.
  2. A Cross-Sectional Study of Cannabidiol Users. https://pmc.ncbi.nlm.nih.gov/articles/PMC6043845/ Accessed December 2, 2025.
  3. Molecular Targets of the Phytocannabinoids-A Complex Picture. https://pmc.ncbi.nlm.nih.gov/articles/PMC5345356/ Accessed December 2, 2025.
  4. Pharmacotherapeutic considerations for use of cannabinoids to relieve pain in patients with malignant diseases. https://pmc.ncbi.nlm.nih.gov/articles/PMC5922297/ Accessed December 2, 2025.
  5. A double-blind, randomized, placebo-controlled study of the safety and effects of CBN with and without CBD on sleep quality. https://pubmed.ncbi.nlm.nih.gov/37796540/ Accessed December 2, 2025.
  6. Cannabidiol, cannabinol and their combinations act as peripheral analgesics in a rat model of myofascial pain. https://pubmed.ncbi.nlm.nih.gov/31158702/ Accessed December 2, 2025.